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THE REGENERATION EFFECT
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The Regenerative Healing Properties of Select Mushrooms
(C) 2012 by John W. Apsley, II, MD(E), ND, DC  www.doctorapsley.com

All information contained herein is for educational purposes only. Always consult with a physician trained in your area of interest before starting any type of health program.  No health claims or representations of any kind, implied or otherwise, are intended by Dr. Apsley to those wishing to incorporate into their daily program said educational intended recommendations.

 
For all product resources, click: [HERE] 

 

 

For the first time, select mushroom powders from the rarest strains are available online for about half the price of the most highly sought after name brands only found in professional clinics or top-end health food stores. Make no mistake folks, with such a price structure tied to such a powerful food product, this translates into one of the greatest health values of our modern age. Put simply, if you are looking for the most bang for the buck, the buck stops here!

 

(Special Advisory: Folks with known allergy to edible mushrooms should avoid consumption of any mushroom product until after consulting their physician. Also, the healing properties of select mushrooms can be powerful. Some folks may feel sluggish when first taking healing mushroom powders, or even experience detoxification symptoms such as fatigue, mental fog, mild headache, joint discomfort, muscle discomfort, and mild intestinal responses such as loose stools or more rarely mild nausea. Reducing dosage by half and increasing daily water intake to 1 ounce of water ingested for every pound of body weight will often clear these detoxification responses within 24 hours. Others must first stop taking mushrooms altogether for 24 hours, then take baby steps leading up to the full dosage schedule. For example, for the most sensitive individuals with the furthest to go for a full recovery, taking 1/4 teaspoon per day for three days may be all that can be tolerated. Then once this dose is tolerated, during the next three days, dosage can be moved up to 1/2 teaspoon per day. Drinking the appropriate amount of water appears to be one key to locking in tolerance. For those most sensitive, it is a testiment to the healing powers of the mushrooms when detoxification symptoms arise. So long as no allergies are present, the above schedule can continue increasing until the full dosage desired is attained, then continued at the proper level as described below.) 

 

The following attributes can be used to best describe novel, select mushroom food powders.

 

Regenerative Properties*

 

Four Pillars - There is clear and compelling scientific evidence that select mushrooms trigger and ignite at least 3 out of 4 members of the Four Pillars. They offer excellent detoxification enhancement by way of their ability to restore optimal levels of the major detoxifying enzyme within cells.1 They are well established to increase cellular energy levels, either by indirectly or directly optimizing oxygen utlization.2 And as far as their super-nourishing character goes, they are known for exciting supra-normal repair and longevity in cells, in part by inducing maturation of progenitor cells and by enhancing immune cells which may spur and guide repair.3, 4, 5, 6

 

1.      Kumar KJ, Chu FH, Hsieh HW, Liao JW, Li WH, Lin JC, Shaw JF, Wang SY. Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation. J Ethnopharmacol. 2011 Jun 14;136(1):168-77.

2.      Ko KM, Leung HY. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007 Mar 27;2:3.

3.      Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S,Nakahata N. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008 Sep;31(9):1727-32.

4.    Kubo N, Myojin Y, Shimamoto F, Kashimoto N, Kyo E, Kamiya K, Watanabe H. Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death. Int J Mol Med. 2005 Mar;15(3):401-6.

5.      Kim SK, Son CG, Yun CH, Han SH. Hericium erinaceum induces maturation of dendritic cells derived from human peripheral blood monocytes. Phytother Res. 2010 Jan;24(1):14-9.

6.    Pero RW, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine. 2005 Apr;12(4):255-63. 

 

From the above, you can understand that select mushrooms are highly regarded as regenerative agents in scientific circles around the world. For further example, specially grown mushrooms appear to offer superior protection to tissues after some of the most toxic injuries, such as exposure to intense radiation. One way they protect is to extend the lives of cells so exposed.1 Additionally, this power is also seen when chemical poisoning occurs in certain cells.2, 3 Perhaps even more illustrative of the regenerative powers of select mushrooms is that their administration greatly speeds proper wound healing beyond what could otherwise occur.4 Even more surprising are the regenerative effects of select mushrooms on repairing the most difficult to heal tissues, such as brain and nerves.5, 6 For example, there is compelling scientific evidence that select mushrooms both excellerate the repair of peripheral nerves as well as induce regeneration in brain cells beyond expectations.5, 6

 

Put into perspective, select mushrooms offer superior healing potential to folks suffering from degenerative conditions in general. And more specifically, select mushrooms appear to provide excellent recovery from poor mental performance and possibly severe brain injuries or advanced nerve degeneration.

 

These regenerative properties are related to the amount of powder consistently administered over several months. 

 

Dosage & Suggested Use:

 

To maximize healing, the first 4 months are the most important phase. This is because most tissues (except for bone and nerve tissues) will turnover once or more during this time frame. That is, most cells live, replicate once and die over a 24 hour to 4 month time frame. By providing all the right factors for repair, the next generation of these cells have the greatest chance to bring on exceptional repair. It may be optimal during the first month of this first four month time period to consider what is called a "loading dosage schedule."

1. For the average adult weighing 170 pounds, one optimal loading dose schedule would be taking 3 teaspoons morning and evening. For those weighing more or less, adjust the dosages up or down by 1 teaspoon for every 30 pounds.

2. During the remaining 3 months, dosage could be reduced to 2 teaspoons taken morning and evening.

3. If results indicate another four month cycle may be beneficial to glean maximal repair, the 2 teaspoons twice daily can be continued.

4. If satisfactory results are achieved during the first four months, maintainence dosages for an average adult may be reduced to 1 teaspoon twice daily.

1.    Kubo N, Myojin Y, Shimamoto F, Kashimoto N, Kyo E, Kamiya K, Watanabe H. Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death. Int J Mol Med. 2005 Mar;15(3):401-6.

2.    Tian J, Chen XM, Li LS. Effects of Cordyceps sinensis, rhubarb and serum renotropin on tubular epithelial cell growth]. Zhong Xi Yi Jie He Za Zhi. 1991 Sep;11(9):547-9, 518.

3.    Li LS, Zheng F, Liu ZH. Experimental study on effect of Cordyceps sinensis in ameliorating aminoglycoside induced nephrotoxicity. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Dec;16(12):733-7.

4. Abdulla MA, Fard AA, Sabaratnam V, Wong KH,Kuppusamy UR, Abdullah N, Ismail S. Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericiumerinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushrooms. 2011;13(1):33-9.

5. Wong KH, Naidu M, David P, Abdulla MA, Abdullah N,Kuppusamy UR, Sabaratnam V. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericiumerinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med. 2011;2011:580752.

6. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S,Nakahata N. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008 Sep;31(9):1727-32.

 

Radioprotective Properties*

 

Protection from radiation is a well-known trait of select mushrooms. Depending upon the level of exposure, 2 to 4 teaspoons daily of select mushroom powders may offer substantial radioprotection. After one month, a maintenance dose of 1 teaspoon daily often serves as a wise precautionary measure. 

1.    Hartman PE, Hartman Z, Citardi MJ. Ergothioneine, histidine, and two naturally occurring histidine dipeptides as radioprotectors against gamma-irradiation inactivation of bacteriophages T4 and P22. Radiat Res. 1988 May;114(2):319-30.

2.    Decome L, De Mİo M, Geffard A, DoucetO, Dumİnil G, Botta A. Evaluation of photolyase (Photosome) repair activity in human keratinocytes after a single dose of ultraviolet B irradiation using the comet assay. J Photochem Photobiol B. 2005 May 13;79(2):101-8. Epub 2005 Jan 22.

3.    Obayashi K, Kurihara K, Okano Y, Masaki H, Yarosh DB. L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts. J Cosmet Sci. 2005 Jan-Feb;56(1):17-27.

4. Lin IH, Hau DM, Chang YH. Restorative effect of Coriolusversicolor polysaccharides against gamma-irradiation-induced spleen injury in mice. Zhongguo Yao Li Xue Bao. 1996 Mar;17(2):102-4.

5. do RosĦrio Freixo M, Karmali A, Arteiro JM. Production ofpolygalacturonase from Coriolus versicolor grown on tomato pomace and its chromatographic behaviour on immobilized metal chelates. J Ind Microbiol Biotechnol. 2008 Jun;35(6):475-84.

 

Anti-aging Properties*

 

The legendary anti-aging forces of select mushrooms has been known to many cultures for millennia. The dosage ranges which may apply to anti-aging programs is identical to the above Regenerative Repair schedule.

1.    Deng-Bo Ji, Jia Ye, Chang-Ling Li, Yu-Hua Wang, Jiong Zhao, Shao-Quing Cai, Antiaging effect of Cordyceps sinensis extract. Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, R.P. China, Department of Nature Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100083, P.R. China.

2. Pero RW, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine. 2005 Apr;12(4):255-63.

 

Antioxidant Properties*

 

Sophisticated antioxidant effects are also intrinsic to select mushrooms. Depending upon your free radical stress level, ingesting from 1 to 2 teaspoons daily can make a lot of sense.

 

1.    Cheah IK, Halliwell B.Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim Biophys Acta. 2012 May;1822(5):784-93.

2.    Markova NG, Karaman-Jurukovska N, Dong KK, Damaghi N, Smiles KA, Yarosh DB.Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system. Free Radic Biol Med. 2009 Apr 15;46(8):1168-76.

 

Extending or Protecting Cellular Life Spans*

 

From the cell level on up, the life of each cell is known to be extended or well protected during its lifespan when receiving regular dosages of select mushroom components. Compelling mammal studies over the past decade are repeatingly confirming these effects. For the average adult, this may translate into ingesting from 2 to 4 teaspoons daily.

 

1.    Paul BD, Snyder SH. The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ. 2010 Jul;17(7):1134-40.

2. Pang ZJ, Chen Y, Zhou M. Polysaccharide Krestinenhances manganese superoxide dismutase activity and mRNA expression in mouse peritoneal macrophages. Am J Chin Med. 2000;28(3-4):331-41.

3. Pang ZJ, Chen Y, Zhou M, Wan J. Effect of polysaccharidekrestin on glutathione peroxidase gene expression in mouse peritoneal macrophages. Br J Biomed Sci. 2000;57(2):130-6.

4. Li HY, Wang XM, Tan JQ, Chen HS. [Effects of Coriolus versicolorpolysaccharides on productivity and longevity in Drosophila melanogaster]. Zhongguo Yao Li Xue Bao. 1993 Nov;14 Suppl:S44-7.

5. Matsunaga K, Iijima H, Aota M, Oguchi Y, Fujii T, Yoshikumi C, Nomoto K.Enhancement of effector cell activities in mice bearing syngeneic plasmacytoma X5563 by a biological response modifier, PSK. J Clin Lab Immunol. 1992 Jan;37(1):21-37.

 

Immune Properties*

 

Select mushrooms exhibit strong support and stimulation to our immune systems. By "amping" up immune defenses, select mushrooms exhibit powerful influences over our white blood cells to ward off even the worst kinds of immune challenges.

Depending upon the state of the immune system (prior suppression or weakness), the more dauntng immune threats may be best served with from 4 to 16 teaspoons daily (1 to 4 teaspoons taken four times daily) during initial stages of nutritional intervention. After the initial stage of immune crises is over, typically after a full month of nutritional intervention, reducing dosages by half may continue best results. Three months thereafter, a suitable long term program consisting of 1 teaspoon taken twice or three times daily should suffice to maintain a most welcomed state of well-being. On occassion, some folks may experience a too rapid activation of their immune system. In such cases, see the section below entitled "Autoimmunity / Hypersensitivity Support." 

 

1.    Ohno S, Sumiyoshi Y, Hashine K, Shirato A, Kyo S, Inoue M. Phase I Clinical Study of the Dietary Supplement, Agaricusblazei Murill, in Cancer Patients in Remission.. 2011;2011:192381.

2. Ishii PL, et al. Evaluation of Agaricusblazei in vivo for antigenotoxic, anticarcinogenic, phagocytic and immunomodulatory activities. Regul Toxicol Pharmacol. 2011 Apr;59(3):412-22.

3. Kankkunen P, Teiril¤ L, Rintahaka J, Alenius H, Wolff H, Matikainen S. (1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages. J Immunol. 2010 Jun 1;184(11):6335-42.

4.    Chanput W, Reitsma M, Kleinjans L, Mes JJ, Savelkoul HF, Wichers HJ. β-Glucans are involved in immune-modulation of THP-1 macrophages.Mol Nutr Food Res. 2012 May;56(5):822-33.

5.    Aoki T, Fenichei RL, Chirgis MA. Immune modulating agents and their mechanisms. Immunol Stud. 1984;25:62-77.

6.    Xiao L, Zhao L, Li T, Hartle DK, Aruoma OI, Taylor EW. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65.

7.    Fujimiya Y, Yamamoto H, Noji M. Peroral effect on tumor progression of soluable B-1,6 glucans prepared by acid treatment from Agaricus blazei, Agaricaceae Higher Basidiomycetes. Int. J Med Mushrooms. 2000;2:43-9.

8. Jeong SC, Yang BK, Kim GN, Jeong H, Wilson MA, Cho Y, Rao KS, Song CH. Macrophage-stimulating activity of polysaccharides extracted from fruiting bodies of Coriolusversicolor (Turkey Tail Mushroom). J Med Food.2006 Summer;9(2):175-81.

 

  Natural Killer Cell Activation*

 

For example, a quintessential member of our white blood cells are called Natural Killer (NK) cells. Select mushrooms readily induce hardy activation of our NK cells. Suggested dosage schedules are as above. (Special Advisory: For those with known autoimmune challanges, allergies, intolerances or hypersensitivities, see section entitled, "Autoimmunity / Hypersensitivity Support" below.)

 

1.    Salvucci O. Differential regulation of interleukin-12- and interleukin -15- induced natural killer cell activation by interleikin-4. Eur J. Immunol. 1996;26(11):2736-41.

2. Nakamura K, Matsunaga K. Susceptibility of natural killer (NK) cells to reactive oxygen species (ROS) and their restoration by the mimics of superoxide dismutase (SOD). Cancer BiotherRadiopharm. 1998 Aug;13(4):275-90.

3. Kodama N, Komuta K, Nanba H. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients . J MedFood. 2003 Winter;6(4):371-7.

4. Kim SP, Kang MY, Kim JH, Nam SH, Friedman M. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J AgricFood Chem. 2011 Sep 28;59(18):9861-9.

 

Dendritic Cell Activation*

 

One of the hottest areas of research concerning reactivation of immune function concerns dendritic cells. By activating and mobilizing dendritic cells, this initiates the maturation and function ofimmune cells, empowering their ability to take on the more serious immune challenges. Suggested dosage schedules are as above. In this manner, select mushrooms bear much fruit in the mission of immune reactivation. (Special Advisory: For those with known autoimmune challanges, allergies, intolerances or hypersensitivities, see next section below.)

1. Kanazawa M, Mori Y, Yoshihara K, Iwadate M, Suzuki S, Endoh Y, Ohki S, Takita K, Sekikawa K, Takenoshita S. Effect of PSK on the maturation of dendritic cells derived from human peripheral blood monocytes. ImmunolLett. 2004 Feb 15;91(2-3):229-38.

2. F¸rland DT, Johnson E, Tryggestad AM, Lyberg T, Hetland G. An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vitro. Cytokine. 2010 Mar;49(3):245-50.

3. Masuda Y, Ito K, Konishi M, Nanba H. A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunol Immunother. 2010 Oct;59(10):1531-41.

4. Kim SK, Son CG, Yun CH, Han SH. Hericium erinaceum induces maturation of dendritic cells derived from human peripheral blood monocytes. Phytother Res. 2010 Jan;24(1):14-9.

Autoimmunity / Hypersensitivity Support*

 

Also today, autoimmunity is ravaging many folks. Folks may also be hypersensitive or intolerant of many foods, including mushrooms. Initial hypersensitivity reactions may involve headache, general malaise, joint pain, lose stools, even nausea. Allergic reactions indicate mushroom ingestion should be discontinued until a physician can be consulted. Allergic reactions are very rare, but should they arise are of concern. The more concerning allergic reactions would be difficulty breathing or swallowing or swelling of the face or other body part. If these symptoms arise, consult your physician immediately.

 

Providing no specific allergy to edible mushrooms exists, hypersensitive individuals may find it best to start out with just  Âĵ teaspoon - either once or up to three times daily for the first week. Then such individuals may find they can successfully double their daily dose or simply hold to their current dosage schedule. After another week, many such cases can once again double their dose to 1 teaspoon once or even up to three times daily. Then after another week or more, such individuals can try to double their daily dose again. Soon, results often speak for themselves guiding those with autoimmune or hypersensitivities exactly the correct daily dose for them. Select mushrooms can, when taken regularly, calm and balance these difficult to manage inflammatory state. To support developing tolerance, be sure to drink lots of pure, mineralized water daily. Suggested water intake is 1 ounce of water for each pound of body weight, over and above any other liquids consumed.

 

1.    Morimasa K, Yamana S, Matsueda H. Immunostimulant therapy with protein bound polysaccharide preparation in patients with SLE or RA. Clinical Immunology. 1980;12:393-8.

2. Hetland G, Johnson E, Lyberg T, Kvalheim G. The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation. Adv Pharmacol Sci. 2011;2011:157015.

3. F¸rland DT, Johnson E, Saetre L, Lyberg T, Lygren I, Hetland G. Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on expression of cytokines and calprotectin in patients with ulcerative colitis and Crohn's disease. Scand J Immunol. 2011 Jan;73(1):66-75.

4. Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A. Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis. Arthritis Rheum. 2012 Jan;64(1):232-42.

 

Liver Performance*

 

The Liver is our key metabolic organ. All immunity and energy production are heavily determined by proper liver metabolism. Liver problems are now running rampant among our developed populations world-wide. Select mushrooms can dramatically improve liver function and liver metabolism, while protecting it from certain chemical assaults. Ingesting from 2 to 8 teaspoons daily may offer a wide range of positive effects upon the liver. Energy levels may significantly recover to help gauge best daily dosage amounts for each individual. Long term dosages may settle in for many folks concerned about their liver at 1 teaspoon taken with each meal, or three times daily.

 

1.    Kiho T, Yamane A. Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultured mycelia of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol Pharm Bull. 1996;19(2):294-6.

2.    Dai G, Bao T, Xu C, Cooper R, Zhu JS. CordyMax Cs-4 improves steady-state bioenergy status in mouse liver. J Altern Complement Med. 2001 Jun;7(3):231-40.

3. Yeung JH, Or PM. Polysaccharide peptides from Coriolusversicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine. 2011 Oct 15;18(13):1170-5.

4. Kumar KJ, Chu FH, Hsieh HW, Liao JW, Li WH, Lin JC, Shaw JF, Wang SY. Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation. J Ethnopharmacol. 2011 Jun 14;136(1):168-77.

5. Huang CH, Chang YY, Liu CW, Kang WY, Lin YL, Chang HC, Chen YC. Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage. J Agric Food Chem. 2010 Mar 24;58(6):3859-66.

6. Ao ZH, Xu ZH, Lu ZM, Xu HY, Zhang XM, Dou WF. Niuchangchih (Antrodiacamphorata) and its potential in treating liver diseases. J Ethnopharmacol. 2009 Jan 21;121(2):194-21.

 

Pancreas Performance*

 

In addition to liver support, select mushrooms also influence healthy pancreatic performance. For the average adult, blood sugar impairment may be greatly aided by regular intake of 2 to 4 teaspoons daily of select mushroom powders. More many adults not seriously overweight, for the long term taking 1 teaspoon with each meal may be just right.

 

1.    Bourlon PM, Billaudel B, Faure-Dussert A. Influence of vitamin D3 deficiency and 1, 25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. Journal of Endocrinology, 1999;160:87-95.

2. Lo HC, Hsu TH, Chen CY. Submerged culture mycelium and broth of Grifola frondosa improve glycemic responses in diabetic rats. Am J Chin Med. 2008;36(2):265-85.3.

3. Lo HC,Hsu TH, Tu ST, Lin KC. Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Am J Chin Med. 2006;34(5):819-32.

4. Lo HC, Tu ST, Lin KC, Lin SC. The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin. Life Sci. 2004 Apr 23;74(23):2897-908.

5. Li FH, Liu P, Xiong WG, Xu GF. [Effects of corydyceps polysaccharide on liver fibrosis induced by DMN in rats]. Zhongguo Zhong Yao Za Zhi. 2006 Dec;31(23):1968-71.

 

Energy Inducing Properties*

 

Today our culture is experiencing a crisis of lack of mind/body energy. Many folks walk around tired all the time. Regular ingestion of select mushroom powders (2 teaspoons daily) often rapidly corrects such situations handily. Select mushrooms may boost energy (ATP) by up to 30% in short order when taking from 2 to 4 teaspoons daily. Smaller adults may find cutting this dosage schedule in half is just as effective. 

 

1.   Ko KM, Leung HY. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007 Mar 27;2:3.

2. Siu KM, Mak DH, Chiu PY, Poon MK,Du Y, Ko KM. Dai G, Bao T, Xu C, Cooper R, Zhu JS. CordyMax Cs-4 improves steady-state bioenergy status in mouse liver.J Altern Complement Med. 2001 Jun;7(3):231-40.

 

Endurance Performance*

 

Athletes and fitness fans often report astounding results when consuming select mushroom powders. Many high performance driven athletes will take from 3 to 6 teaspoons a day in heavy training programs, while the more down to earth fitness enthusiast will find 2 to 4 teaspoons daily the right fit for them. 

1.    Ferreira LF, Campbell KS, Reid MB. Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue. Med Sci Sports Exerc. 2011 Jun;43(6):1025-31.

2.    Koh et al, 2003 J.H. Koh, K.M. Kim. Anti fatigue and anti-stress effects of the hot water fraction from mycelia of Cordyceps sinesis. Biological and Pharmaceuetin. 2003;26:691-4.

3. Siu KM, Mak DH, Chiu PY, Poon MK, Du Y, Ko KM. Pharmacological basis of 'Yin-nourishing' and 'Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb. Life Sci. 2004 Dec 10;76(4):385-95.

 

Cardiovascular Performance*Augmenting heart function is now simple to do with select mushroom powders. Depending upon the desired effect, from 2 to 8 teaspoons daily can be taken for the first month. Thereafter, reducing the dose by half often proves to be just the perfect amount for many individuals.

1.    Che Ys, Lin Lz. Clinical observation of therapeutic effects of JinShuBao on coronary heart disease, hyperlipidemia, and blood rheology. Chinese Traditional Herbal Drugs. 1996.

2. Chang ST, Wasser SP. The role of culinary-medicinal mushrooms on human welfare with a pyramid model for human health. Int J Med Mushrooms.2012;14(2):95-134.

3. Wasser SP. Current findings, future trends, and unsolved problems in studies of medicinal mushrooms. Appl Microbiol Biotechnol. 2011 Mar;89(5):1323-32. 

 

Mental Performance*

As never before, our brain cells and nerves are facing enormous threats. Whether the risks arise due to frequent use of cell phones, or intensive work stress, or a major circulatory event, or even a head injury, select mushrooms may offer a most welcomed solution. 

 

Brain injury and dysfunction are areas crippling many folks and include:

  • Memory Loss,
  • Learning impairment,
  • Depression,
  • Anxiety.

 

Select mushroom powders can help regenerate nerves when needed and fortify nerve function, resulting in re-invigorated brain function. Dosages may run from 2 to 6 teaspoons daily, or more, depending upon the neurological challenge. Since we are discussing a super food here, experimenting to determine just what is the prefect daily amount for you in any given situation is allowed! 

 

1.    Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008 Sep;31(9):1727-32.

2. Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericiumerinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011 Feb;32(1):67-72.

3. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericiumerinaceus intake. Biomed Res. 2010 Aug;31(4):231-7.

4. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericiumerinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res.2009 Mar;23(3):367-72.

5. Park YS, Lee HS, Won MH, Lee JH, Lee SY, Lee HY. Effect of an exo-polysaccharide from the culture broth of Hericiumerinaceus on enhancement of growth and differentiation of rat adrenal nerve cells. Cytotechnology.2002 Sep;39(3):155-62.

6. Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericiumerinaceus extract on myelination process in vitro. Fiziol Zh. 2003;49(1):38-45.

7. Cheng Z, He W, Zhou X, Lv Q, Xu X, Yang S, Zhao C, Guo L. Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro. Eur J Pharmacol.2011 Aug 16;664(1-3):20-8.

8. Wang LC, Wang SE, Wang JJ, Tsai TY, Lin CH, Pan TM, Lee CL. In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment. Appl Microbiol Biotechnol. 2012 Jun;94(6):1505-19.

 

Super-Nourishment & Weight Optimizing Properties*

 

Select strains of mushrooms are highly nutritious and satsifying to the body. Plus they taste great when mixed with other foods and beverages. This often translates into being satisfied with less food while attaining an ideal weight profile. Both athletes as well as those who struggle with weight issues often find they are delighted with consuming select mushroom powder on a maintenance basis. With its full complement of:

  • Proteins and complete amino acid profile,
  • Abundant essential oils,
  • Healthy carbohydrates and fiber,
  • Plus antioxidants,
  • Broadspectrum vitamins,
  • Wide-scope of Minerals,
  • Adaptogens,
  • Select phyto-immunomodulators, and
  • colloidal Regeneration Factors (cRFsTM)...
     

 

taking 1 to 2 teaspoons daily of select mushroom powder will add huge healthy value to anyone's diet.   

1. Smith AE, Fukuda DH,Kendall KL, Stout JR. The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance. J Int Soc Sports Nutr. 2010 Feb 15;7:10.

2. Wu MF, Hsu YM, Tang MC, Chen HC, Chung JG, Lu HF, Lin JP, Tang NY, Yeh C, Yeh MY. Agaricus blazei Murill extract abrogates CCl4-induced liver injury in rats. In Vivo. 2011 Jan-Feb;25(1):35-40.

3. Krupodorova TA, Barshteyn VY, Bisko NA, Ivanova TS. Some macronutrient content in mycelia and culture broth of medicinal mushrooms cultivated on amaranth flour. Int J Med Mushrooms.2012;14(3):285-93

4. Wu X, Liu F, Zeng W, Zhong G, Tu Y, Chen S. [Relevance analysis of amino acid contents in cultivated Cordyceps and cultivation materials]. Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(2):142-4.

 

Safety

 

The FDA recognizes edible mushrooms are GRAS (generally regarded as safe).

1.    Schauss AG, Vİrtesi A, Endres JR, Hirka G, Clewell A, Qureshi I, Pasics I. Evaluation of the safety of the dietary antioxidant ergothioneine using the bacterialreverse mutation assay. Toxicology. 2010 Nov 28;278(1):39-45.

2. Hor SY, Ahmad M, Farsi E, Lim CP, Asmawi MZ, Yam MF. Acute and subchronic oral toxicity of Coriolus versicolor standardized water extract in Sprague-Dawley rats. J Ethnopharmacol. 2011 Oct 11;137(3):1067-76.

 

For more info, see: [Here]

 

 

Select Bibliography

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2) Kakkura B. Variations in erythrocyte antioxidant glutathione peroxidase activity during the menstrual cycle. Dept of Obstetrics and Gynecology, University of Siena, Italy, Online Pub, 2006.

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5) Lee P. Mechanism of neuronal death in Down's syndrome. J Neural Trausm. 2004;Supp 57:233-45.

6) Kanman K, Jain S. Oxidative stress and apoptosis. Pathophysiology. 2000;7:153-63.

7) Grundemann D, et al. Discovery of the ergothionine Transporter. Department of Pharmacology, University of Cologne, Germany, 2004.

8) Kutner & Jablonska, (2000), Vitamin D deficiency associated with cancers. In: Grant 2002: Hansen & Hamberg, 2001: Online Publication.

9) Billaudel B, Barakat, L. Vitamin D3 deficiency and alterations of glucose metabolism in rat endocrine pancreas. Diabetes Metabolism. 1998;24:344-50.

10) S.P. Wasser, Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbial Biotechnology. 2002;60:258-74.

11) Borchers AT, Stern JS, Hackman RM. Mushrooms, tumors and immunity. Soc Exp Biol Med. 1999;221:281-93.

12) Fullerton SA, Samadi AA, (2000), Induction of apoptosis in human prostatic cancer cells with beta-glucan from Maitake. Mol Urol 4: pp 7-13.

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14) Sharon N, Halina Lis H. Carbohydrates in Cell Recognition. Scientific America. 1993 Jan.

15) Won S-Y, Park E-H. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris.  College of Pharmacy, Sookmyung Women's University, Seoul 140-742, South Korea, Journal of Ethnopharmacology. 2005 Jan 15;96(3):555-61.

16) Chiou et al. Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps Sinensis. Life Sciences. 2000;66:1369-76.
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20) Bourlon P M, Billaudel B, Faure-Dussert A. Influence of vitamin D3 deficiency and 1, 25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. Journal of Endocrinology. 1999;160:87-95.
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28) Che Y, Lin L. Clinical observation of therapeutic effects of JinShuBao on coronary heart disease, hyperlipidemia, and blood rheology. Chinese traditional herbal drugs. 1996. 

29) Kiho T, Yamane A, Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultured mycelia of Cordyceps sinensis and its effect on glucose metabolism in  mouse liver. Biol Pharm Bull. 1996;19(2):294-6. 

30) Shao G, You Z. Treatment of hyperlipidemia with Cordyceps sinensis; a double blind placebo control trial. Int j oriental Med 1990;15(2);77-80.

31) Mizuno T, et al. Antitumor active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake Biosci, Biotech, Biochem. 1992;56(2):347-8. 

32) Konno S, et al. A possible hypoglycemic effect of Maitake mushroom on type 2 diabetic patients, Diabetic Medicine. 2001 Dec;18(12):1010. 

33) Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H. Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway. J Nutr Biochem. 2006 Aug;17(8):525-30. 

34) Shu J-S, Halpern GM, Jones K. The Scientific Rediscovery of an Ancient Chinese Herbal-Medicine: Cordyceps-sinensis. Journal of Alternative and Complementary Medicine. 1998;4(3):289-303.
35) Tsukagoshi S, et al. Krestin (PSK). Cancer Treatment Reviews. 1984;11:131-55.

36) Ng TB. A Review of Research on the Protein-Bound Polysaccharide (Polysaccharopeptide, PSP) from the Mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmac. 1998;30(1):1-4.

37) Fullerton SA, et al. Induction of Apoptosis in Human Prostatic Cancer Cells with β-Glucan (Maitake Mushroom Polysaccharide). Mol Urol. 2000 Spring;4(1):7-13.

38) Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbiology biotechnology. 2002;60:258-74.

39) Hseu Y-C, et al. Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia Camphorata. Food and Chemical Toxicology 2007;45 :1107-15.

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43) Chang R. Functional properties of edible mushrooms. Nutr Rev. 1996;54(11):S91-S93.

44) Salvucci O. Differential regulation of interleukin-12- and interleukin -15- induced natural killer cell activation by interleikin-4. Eur J. Immunol. 1996;26(11):2736-41.

45) Ukai  S. Antitumor activity on sarcoma 180 of the polysaccharides from Tremella fuciformis. Berk. Chem Phara Bull. (Tokyo). 1972;20(10):2293-4.

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47) Son C-G, et al. Induction of murin interleukin-1 beta expression by water-soluble components from Hericium erinaceum. Acta Pharmacol Sin. 2006 Aug;27(8):1058-64. 

48) Ji D-B, et al. Antiaging effect of Cordyceps sinensis extract. Phytother Res. 2009 Jan;23(1):116-22.

49) Reay J, Kim SH, Lockhart E., Kolls J, Robbins PD. Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response. Cancer Gene Ther. 2009 Oct;16(10):776-85.
50) 
Zaidman B-Z, Yassin M, Mahajna J, Wasser SP. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol. 2005 Jun;67(4):453-68.

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.